Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts.

Cancer research - 15 Jun 1996

Yan T, Oberley L W, Zhong W, St Clair D K

Abstract excerpt

Manganese superoxide dismutase (MnSOD) has been found to be low in a wide range of tumor cells as well as in vitro-transformed cell lines and has been implicated as a new type of tumor suppressor gene. The relationship between MnSOD activity and the malignant phenotype was studied by transfection of MnSOD cDNA into the SV40-transformed human fibroblast cell line WI-38 VA13 subline 2RA. The integration and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Cell Line, Transformed
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Phenotype

Share to Superoxide Dismutase

Share to Transfection

Source

Identifiers

PMID: 8665527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts.PMID 8665527Read ↗

Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutaseSemantic proximity Read ↗

Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal.Semantic proximity Read ↗

Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase.Semantic proximity Read ↗

Alteration of cellular phenotype and responses to oxidative stress by manganese superoxide dismutase and a superoxide dismutase mimic in RWPE-2 human prostate adenocarcinoma cells.Semantic proximity Read ↗

Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.Semantic proximity Read ↗

Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype.Semantic proximity Read ↗

Manganese superoxide dismutase expression as a function of genotype and lung cancer pathology.Semantic proximity Read ↗

Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase.Semantic proximity Read ↗

Induction of apoptosis by adenovirus-mediated manganese superoxide dismutase overexpression in SV-40-transformed human fibroblasts.Semantic proximity Read ↗

Manganese superoxide dismutase overexpression changes plating efficiency bidirectionally according to change in redox for SaOS2 human osteosarcoma cell line.Semantic proximity Read ↗

Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells.Semantic proximity Read ↗

Mutations in the SOD2 promoter reveal a molecular basis for an activating protein 2-dependent dysregulation of manganese superoxide dismutase expression in cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.