KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene

doi:10.1093/jnci/88.23.1731

Article

KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene

4 Dec 1996

Abstract excerpt

BACKGROUND: Microcell-mediated transfer of chromosome 6 into human C8161 and MelJuSo melanoma cell suppresses their ability to metastasize by at least 95% without affecting their tumorigenicity. This observation demonstrates that the ability to metastasize is a phenotype distinct from tumor formation and suggests that tumorigenic cells acquire metastatic capability only after accumulating additional genetic...

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