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Article

Mutant p53 induces SIRT3/MnSOD axis to moderate ROS production in melanoma cells.

Archives of biochemistry and biophysics - 15 Jan 2020

Torrens-Mas Margalida, Cordani Marco, Mullappilly Nidula, Pacchiana Raffaella, Riganti Chiara, Palmieri Marta, Pons Daniel G, Roca Pilar, Oliver Jordi, Donadelli Massimo

Abstract excerpt

The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 isoforms can acquire oncogenic properties referred to as gain-of-function (GOF). In this study, we used wild-type (A375) and mutant p53 (MeWo) melanoma cell lines to assess the regulation of the mitochondrial antioxidant manganese superoxide dismutase (MnSOD) by mutant p53. The effects of mutant p53 were evaluated by qPCR,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31812668
DOI: 10.1016/j.abb.2019.108219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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