Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase

1 Jan 1992

Abstract excerpt

Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation-, but not chemically-induced neoplastic transformation. This finding demonstrates that oxidative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Effects of Radiation Exposure
Share to Glutathione Transferases and Polymorphisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1485915
DOI: 10.1002/mc.2940060404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutasePMID 1485915Read ↗

Conditional radioresistance of Tet-inducible manganese superoxide dismutase bone marrow stromal cell lines.Semantic proximity Read ↗

Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts.Semantic proximity Read ↗

Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal.Semantic proximity Read ↗

Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts.Semantic proximity Read ↗

Manganese superoxide dismutase and glutathione peroxidase-1 contribute to the rise and fall of mitochondrial reactive oxygen species which drive oncogenesis.Semantic proximity Read ↗

The superoxide dismutase mimetic GC4419 enhances tumor killing when combined with stereotactic ablative radiationSemantic proximity Read ↗

Alteration of cellular phenotype and responses to oxidative stress by manganese superoxide dismutase and a superoxide dismutase mimic in RWPE-2 human prostate adenocarcinoma cells.Semantic proximity Read ↗

Mitochondrial Localization of Superoxide Dismutase is Required for Decreasing Radiation-Induced Cellular DamageSemantic proximity Read ↗

Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase.Semantic proximity Read ↗

Oxidative Damage to Mitochondria Enhanced by Ionising Radiation and Gold Nanoparticles in Cancer CellsSemantic proximity Read ↗

Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species.Semantic proximity Read ↗

Mitochondrial Targeting of a Catalase Transgene Product by Plasmid Liposomes Increases RadioresistanceIn VitroandIn VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.