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Article

Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

The EMBO journal - 1 Jun 1995

Raabe T, Olivier J P, Dickson B, Liu X, Gish G D, Pawson T, Hafen E

Abstract excerpt

The Drk SH3-SH2-SH3 adaptor protein has been genetically identified in a screen for rate-limiting components acting downstream of the Sevenless (Sev) receptor tyrosine kinase in the developing eye of Drosophila. It provides a link between the activated Sev receptor and Sos, a guanine nucleotide release factor that activates Ras1. We have used a combined biochemical and genetic approach to study the interactions...

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Identifiers

PMID: 7781603
DOI: 10.1002/j.1460-2075.1995.tb07248.x
PMCID: PMC398364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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