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Article

The internal quaternary ammonium receptor site of Shaker potassium channels.

Neuron - 1 Mar 1993

Choi K L, Mossman C, Aubé J, Yellen G

Abstract excerpt

Quaternary ammonium (QA) compounds inhibit K+ conductance by entering and occluding the open pore of voltage-activated K+ channels. We characterized the effects of a series of alkyl-triethylammonium blockers on the Shaker K+ channel and tested them on a series of site-directed mutants of the channel protein in order to define the structural features of the binding sites. We found that mutations in two regions of...

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Identifiers

PMID: 8461140
DOI: 10.1016/0896-6273(93)90340-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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