Molecular determinants of external barium block in Shaker potassium channels.

Abstract excerpt

Mutations in the outer pore region of Shaker K+ channels (T449 and D447) can influence external Ba2+ block. Substitution of T449 by A, V or Y differentially reduced Ba2+ block primarily by decreasing the blocking rate. Substitution of D447 by N resulted in a non-conducting channel with apparently normal gating currents. External Ba2+ can speed the OFF gating current of a different non-conducting mutant, W434F;...

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