Molecular basis of rifampin resistance in Mycobacterium leprae.

doi:10.1128/AAC.37.3.414

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Article

Molecular basis of rifampin resistance in Mycobacterium leprae.

Antimicrobial agents and chemotherapy - 1 Mar 1993

Honore N, Cole S T

Abstract excerpt

Rifampin is currently the most potent drug used in leprosy control programs. We show that the rifampin resistance which emerged in nine patients with lepromatous leprosy, who had received rifampin monotherapy, stemmed from mutations in the rpoB gene, which encodes the beta subunit of RNA polymera...

Topics

Amino Acid Sequence
Animals
Base Sequence
Conserved Sequence
Drug Resistance, Microbial
Genes, Bacterial
Humans
Leprosy
Mice
Molecular Sequence Data
Mutation
Mycobacterium leprae
Rifampin

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