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Article

Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae.

Scientific reports - 22 Mar 2018

Vedithi Sundeep Chaitanya, Malhotra Sony, Das Madhusmita, Daniel Sheela, Kishore Nanda, George Anuja, Arumugam Shantha, Rajan Lakshmi, Ebenezer Mannam, Ascher David B, Arnold Eddy, Blundell Tom L

Abstract excerpt

The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological factors for rifampin resistance in leprosy. In the present study, we identified mutations corresponding to rifampin resistance in relapsed leprosy cases from three hospitals in southern India which treat leprosy patients. DNA was extracted from...

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Identifiers

PMID: 29567948
DOI: 10.1038/s41598-018-23423-1
PMCID: PMC5864748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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