Article
Isolation of the gene for the beta subunit of RNA polymerase from rifampicin-resistant Mycobacterium tuberculosis and identification of new mutations.
American journal of respiratory cell and molecular biology - 1 Dec 1994
Donnabella V, Martiniuk F, Kinney D, Bacerdo M, Bonk S, Hanna B, Rom W N
Abstract excerpt
Tuberculosis (TB) is one of the most important infections worldwide, with an estimated incidence of 10 million active cases per year. Rifampicin is a key component of the first-line therapy used in the treatment of tuberculosis. In Escherichia coli and Mycobacterium leprae, rifampicin has been sh...
Topics
- Cloning, Molecular
- DNA Mutational Analysis
- DNA, Bacterial
- DNA-Directed RNA Polymerases
- Drug Resistance, Microbial
- Escherichia coli
- Gene Dosage
- Genes, Bacterial
- Genomic Library
- Humans
- Mutation
- Mycobacterium
- Mycobacterium tuberculosis
- Plasmids