Article
Isolation of the gene for the beta subunit of RNA polymerase from rifampicin-resistant Mycobacterium tuberculosis and identification of new mutations.
American journal of respiratory cell and molecular biology - 1 Dec 1994
Donnabella V, Martiniuk F, Kinney D, Bacerdo M, Bonk S, Hanna B, Rom W N
Abstract excerpt
Tuberculosis (TB) is one of the most important infections worldwide, with an estimated incidence of 10 million active cases per year. Rifampicin is a key component of the first-line therapy used in the treatment of tuberculosis. In Escherichia coli and Mycobacterium leprae, rifampicin has been shown to inhibit the beta subunit of RNA polymerase. The gene (rpoB) encoding this enzyme has been described in both...
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