Article
Mutation at codon 442 in the rpoB gene of Mycobacterium leprae does not confer resistance to rifampicin.
Leprosy review - 1 Mar 2016
Lavania Mallika, Hena Abu, Reja Hasanoor, Nigam Astha, Biswas Nibir Kumar, Singh Itu, Turankar Ravindra P, Gupta Ud, Kumar Senthil, Rewaria Latika, Patra Pradip K R, Sengupta Utpal, Bhattacharya Basudeb
Abstract excerpt
BACKGROUND: Rifampicin is the major drug in the treatment of leprosy. The rifampicin resistance of Mycobacterium leprae results from a mutation in the rpoB gene, encoding the β subunit of RNA polymerase. As M. leprae is a non-cultivable organism observation of its growth using mouse food-pad (MFP) is the only Gold Standard assay used for confirmation of "in-vivo" drug resistance. OBJECTIVE: Any mutation at...
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