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Article

A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infection.

The Journal of experimental medicine - 1 Apr 1993

Simon J H, Somoza C, Schockmel G A, Collin M, Davis S J, Williams A F, James W

Abstract excerpt

CD4 is the primary receptor for the human immunodeficiency virus type 1 (HIV-1). Early mutational studies implicated a number of residues of CD4, centered in the region 41-59, in binding to gp120. However, further mutational analyses, together with studies using inhibitory antibodies or CD4-derived peptides, have suggested that other regions of CD4 are also involved in binding or postbinding events during...

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Identifiers

PMID: 8459222
DOI: 10.1084/jem.177.4.949
PMCID: PMC2190986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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