Article
Human immunodeficiency virus type 1 entry into murine cell lines and lymphocytes from transgenic mice expressing a glycoprotein 120-binding mutant mouse CD4.
AIDS research and human retroviruses - 1 Jul 1996
Wieder K J, Chatis P, Boltax J, Wieder I, Nuovo G, Strom T B
Abstract excerpt
Human CD4, the receptor for the gp120 envelope glycoprotein of HIV-1, is the route for viral entry into CD4+ cells; other cellular factors may cooperate with CD4 to facilitate HIV-1 entry into human cells. Human CD4 expressed on murine cells does not readily mediate HIV-1 entry, which may reflect...
Topics
- Amino Acid Sequence
- Animals
- CD4 Antigens
- Cell Line
- Flow Cytometry
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Transfection
- Virus Replication