Article
Coreceptor function of mutant human CD4 molecules without affinity to gp120 of human immunodeficiency virus.
The Journal of biological chemistry - 7 Jul 2000
Tachibana M, Siddiqi M A, Ikegami Y, Eshima K, Shirota-Someya Y, Tahara-Hanaoka S, Koito A, Iizuka M, Shinohara N
Abstract excerpt
Despite extensive mutational studies on the human CD4 molecule and its affinity to human immunodeficiency virus (HIV) envelope glycoprotein gp120, coreceptor functions of such mutant molecules have only been examined by indirect measurement of their affinity to class II major histocompatibility complex (MHC) molecules. In this report, coreceptor functions of mutant human CD4 molecules, which have no or reduced...
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