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Article

Determinants of the trans-dominant negative effect of truncated forms of the CCR5 chemokine receptor.

The Journal of biological chemistry - 14 Dec 2001

Chelli M, Alizon M

Abstract excerpt

The human immunodeficiency virus, type 1 (HIV-1) entry process is triggered by interaction between the viral envelope and a seven membrane-spanning domain receptor at the cell surface, usually the CCR5 chemokine receptor. Different naturally occurring mutations in the CCR5 gene abolish receptor function, the most frequent being a 32-nucleotide deletion resulting in a truncated protein (Delta32) lacking the last...

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PMID: 11600494
DOI: 10.1074/jbc.M106432200

Genes

CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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