Contribution of charged amino acids in the CDR2 region of CD4 to HIV-1 gp120 binding.

Article

Contribution of charged amino acids in the CDR2 region of CD4 to HIV-1 gp120 binding.

Journal of acquired immune deficiency syndromes - 1 Jan 1992

Choe H R, Sodroski J

Abstract excerpt

Several negatively charged amino acids of the human immunodeficiency virus type 1 (HIV-1) gp120 glycoprotein have been implicated in binding to the CD4 viral receptor. The CD4 region implicated in binding gp120 consists of a hydrophobic ridge protruding from a positively charged surface. To exami...

Topics

Amino Acid Sequence
Amino Acids
Antibodies, Monoclonal
CD4 Antigens
Cell Line
Electrochemistry
HIV Envelope Protein gp120
Humans
Molecular Sequence Data
Mutation
Precipitin Tests

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