Article
Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development.
Mechanisms of development - 1 Apr 2001
Van de Putte T, Zwijsen A, Lonnoy O, Rybin V, Cozijnsen M, Francis A, Baekelandt V, Kozak C A, Zerial M, Huylebroeck D
Abstract excerpt
In a phenotypic screen in mice using a gene trap approach in embryonic stem cells, we have identified a recessive loss-of-function mutation in the mgcRacGAP gene. Maternal protein is present in the oocyte, and mgcRacGAP gene transcription starts at the four-cell stage and persists throughout mouse pre-implantation development. Total mgcRacGAP deficiency results in pre-implantation lethality. Such E3.5 embryos...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.