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Article

<i>C‐myc</i> as a modulator of renal stem/progenitor cell population

22 Jan 2009

Abstract excerpt

The role of c-myc has been well-studied in gene regulation and oncogenesis but remains elusive in murine development from midgestation. We determined c-myc function during kidney development, organogenesis, and homeostasis by conditional loss of c-myc induced at two distinct phases of nephrogenesis, embryonic day (e) 11.5 and e17.5. Deletion of c-myc in early metanephric mesenchyme (e11.5) led to renal hypoplasia...

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PMID: 19161241
DOI: 10.1002/dvdy.21841

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