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Article

Specific sterols required for the internalization step of endocytosis in yeast.

Molecular biology of the cell - 1 Nov 1999

Munn A L, Heese-Peck A, Stevenson B J, Pichler H, Riezman H

Abstract excerpt

Sterols are major components of the plasma membrane, but their functions in this membrane are not well understood. We isolated a mutant defective in the internalization step of endocytosis in a gene (ERG2) encoding a C-8 sterol isomerase that acts in the late part of the ergosterol biosynthetic pathway. In the absence of Erg2p, yeast cells accumulate sterols structurally different from ergosterol, which is the...

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Identifiers

PMID: 10564282
DOI: 10.1091/mbc.10.11.3943
PMCID: PMC25690

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