Transforming activity of mutant human p53 alleles.

doi:10.1002/jcp.1041480309

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Article

Transforming activity of mutant human p53 alleles.

Journal of cellular physiology - 1 Sept 1991

Slingerland J M, Benchimol S

Abstract excerpt

Mutant forms of the p53 gene have been shown to cooperate with an activated ras gene in transforming primary cells in culture. The aberrant proteins encoded by p53 mutants are thought to act in a dominant negative manner in these assays. In vivo data, however, reveal that where p53 has undergone genetic change in tumors, both alleles have been affected. We previously identified a case of human acute myelogenous...

Topics

Alleles
Animals
Cell Transformation, Neoplastic
Cells, Cultured
Fibroblasts
Genes, Dominant
Genes, Recessive
Genes, p53
Genes, ras
Genetic Vectors
Humans
Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Plasmids

Rats

Transfection

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 1918170
DOI: 10.1002/jcp.1041480309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1918170-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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