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Article

Disruption of functions of wild-type p53 by hetero-oligomerization.

International journal of oncology - 1 Sept 1999

Deb D, Chakraborti A S, Lányi A, Troyer D A, Deb S

Abstract excerpt

We report that a p53 segment (p53 del 1-293) containing the oligomerization domain interferes with the functions of wild-type p53. Wild-type p53 inhibits transcription mediated by human cytomegalovirus (CMV) immediate-early promoter significantly; however, co-expression of p53 del 1-293 drastically reduces this repression. We show that wild-type p53 forms hetero-oligomers with p53 del 1-293 suggesting that the...

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Source

Identifiers

PMID: 10427119
DOI: 10.3892/ijo.15.3.413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of functions of wild-type p53 by hetero-oligomerization.PMID 10427119Read ↗

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