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Article

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

Molecular and cellular biology - 1 Dec 1992

Shaulian E, Zauberman A, Ginsberg D, Oren M

Abstract excerpt

Mutations in the p53 gene are most frequent in cancer. Many p53 mutants possess transforming activity in vitro. In cells transformed by such mutants, the mutant protein is oligomerized with endogenous cell p53. To determine the relevance of oligomerization for transformation, miniproteins containing C-terminal portions of p53 were generated. These miniproteins, although carrying no point mutation, transformed at...

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Identifiers

PMID: 1448088
DOI: 10.1128/mcb.12.12.5581-5592.1992
PMCID: PMC360497

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.PMID 1448088Read ↗

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