Article
HLA-DPB1 alleles correlate with risk for multiple sclerosis in Caucasoid and Cantonese patients lacking the high-risk DQB1*0602 allele.
Tissue antigens - 1 Jan 1993
Dekker J W, Easteal S, Jakobsen I B, Gao X, Stewart G J, Buhler M M, Hawkins B R, Higgins D A, Yu Y L, Serjeantson S W
Abstract excerpt
Multiple sclerosis (MS) is a demyelinating disease associated with the HLA-DR2-related haplotype DRB1*1501, DQB1*0602 in Caucasoids and with DQB1*0602 in DR2-positive Cantonese. However, many MS patients do not have the high-risk HLA-D determinants and alternative genes may contribute to the path...
Topics
- Alleles
- Asian People
- Australia
- Autoimmune Diseases
- Ethnicity
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-DP Antigens
- HLA-DP beta-Chains
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Haplotypes
- Hong Kong
- Humans
- Linkage Disequilibrium