Article
HLA-DPB1*0301 is a major risk factor for rheumatoid factor-negative adult rheumatoid arthritis.
Arthritis and rheumatism - 1 Oct 1991
Gao X, Fernandez-Viña M, Olsen N J, Pincus T, Stastny P
Abstract excerpt
HLA-DPB1 alleles were determined using the polymerase chain reaction and allele-specific oligonucleotide probes in Caucasoid patients with rheumatoid arthritis (RA) and in healthy controls. DPB1*0301 was found to be increased in seronegative patients (50.0% versus 10.8% in controls; relative risk = 8.3, P less than 0.0001). With our previous finding that DPB1*0301 is increased in seronegative children with...
Topics
- Adult
- Alleles
- Arthritis, Rheumatoid
- Gene Amplification
- Genetic Linkage
- HLA-DP Antigens
- HLA-DP beta-Chains
- Humans
- Polymerase Chain Reaction
- Rheumatoid Factor
- Risk Factors