Article
HLA-DQB1 genotype in Sardinian multiple sclerosis: evidence for a key role of DQB1 *0201 and *0302 alleles.
Neurology - 1 Apr 1992
Marrosu M G, Muntoni F, Murru M R, Costa G, Pischedda M P, Pirastu M, Sotgiu S, Rosati G, Cianchetti C
Abstract excerpt
We studied HLA-DQB1 haplotypes in 103 unrelated multiple sclerosis (UMS) patients and in 26 related (RMS) patients from 12 families from Sardinia, Italy, where the disease was associated with the HLA-DR4 allele. Using polymerase chain reaction and allele-specific oligonucleotide probes, we found in UMS an increased frequency of the DQB1 *0201 (p = 0.010) and DQB1 *0302 (p = 0.025) alleles, whereas the DQB1 *0301...
Topics
- Alleles
- Female
- Genotype
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Haplotypes
- Humans
- Italy
- Male
- Multiple Sclerosis