Article
Association of susceptibility to multiple sclerosis in Southern Han Chinese with HLA-DRB1, -DPB1 alleles and DRB1-DPB1 haplotypes: distinct from other populations.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 2009
Wu Xiao-Mu, Wang Chaodong, Zhang Kun-Nan, Lin Ai-Yu, Kira Jun-ichi, Hu Guo-Zhu, Qu Xin-Hui, Xiong Ying-Qiong, Cao Wen-Feng, Gong Lin-Yun
Abstract excerpt
Association of HLA class II with multiple sclerosis (MS) has been widely studied in both Western and Oriental populations. However, such an association is not well documented in Chinese. The objective of this study was to examine the association between the susceptibility to conventional MS in Southern Chinese with HLA-DRB1,-DPB1 alleles and putative DRB1-DPB1 haplotypes. Genotyping of HLA-DRB1 and -DPB1 alleles...
Topics
- Adolescent
- Adult
- Aged
- Asian People
- Case-Control Studies
- China
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- HLA-DP Antigens
- HLA-DP beta-Chains
- HLA-DR Antigens