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Article

FcR gamma chain deletion results in pleiotrophic effector cell defects.

Cell - 11 Feb 1994

Takai T, Li M, Sylvestre D, Clynes R, Ravetch J V

Abstract excerpt

The gamma subunit of immunoglobulin Fc receptors is an essential component of the high-affinity receptor for IgG (Fc gamma RIII) and is associated with the high-affinity receptor for IgG (Fc gamma RI) and the T cell receptor-CD3 complex. It is required for both receptor assembly and signal transduction. Targeted disruption of this subunit results in immunocompromised mice. Activated macrophages from gamma...

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PMID: 8313472
DOI: 10.1016/0092-8674(94)90115-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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