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Article

Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors.

Journal of virology - 1 Aug 1995

van den Broek M F, Müller U, Huang S, Aguet M, Zinkernagel R M

Abstract excerpt

Alpha/beta interferon (IFN) and gamma IFN exert widely overlapping biological effects. Still, mice with individually inactivated alpha/beta or gamma receptors exhibit variably severely reduced resistance to infection and altered immune responses. To investigate to what extent the two IFN systems are functionally redundant, we generated mice with a combined receptor defect (AG129 mice). Like mice with individual...

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Identifiers

PMID: 7609046
DOI: 10.1128/JVI.69.8.4792-4796.1995
PMCID: PMC189290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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