Article
Loss of p53 function in colon cancer cells results in increased phosphocholine and total choline.
Molecular imaging - 1 Oct 2004
Mori Noriko, Delsite Robert, Natarajan Kshama, Kulawiec Mariola, Bhujwalla Zaver M, Singh Keshav K
Abstract excerpt
Mutations in the p53 gene are the most frequently observed genetic lesions in human cancers. Human cancers that contain a p53 mutation are more aggressive, more apt to metastasize, and more often fatal. p53 controls numerous downstream targets that can influence various outcomes such as apoptosis, growth arrest, and DNA repair. Based on previous observations using (1)H magnetic resonance spectroscopy (MRS), we...
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