HLA-DQA1 and -DQB1 associations with multiple sclerosis in Sardinia and French Canada: evidence for immunogenetically distinct patient groups.

doi:10.1212/wnl.43.3_part_1.548

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Article

HLA-DQA1 and -DQB1 associations with multiple sclerosis in Sardinia and French Canada: evidence for immunogenetically distinct patient groups.

Neurology - 1 Mar 1993

Haegert D G, Muntoni F, Murru M R, Costa G, Francis G S, Marrosu M G

Abstract excerpt

We analyzed the association of HLA-DQA1 and -DQB1 alleles with multiple sclerosis (MS) in a collaborative study of 116 Sardinian and 75 French Canadian MS patients by the relative predispositional effect method. In French Canadians, MS was positively associated with DQA1*0102 and DQB1*0602, but t...

Topics

Alleles
Canada
Disease Susceptibility
Gene Frequency
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
Haplotypes
Humans
Italy
Multiple Sclerosis

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