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Article

Interaction between HLA-DRB1-DQB1 haplotypes in Sardinian multiple sclerosis population.

PloS one - 1 Jan 2013

Cocco Eleonora, Murru Raffaele, Costa Gianna, Kumar Amit, Pieroni Enrico, Melis Cristina, Barberini Luigi, Sardu Claudia, Lorefice Lorena, Fenu Giuseppe, Frau Jessica, Coghe Giancarlo, Carboni Nicola, Marrosu Maria Giovanna

Abstract excerpt

We performed a case-control study in 2,555 multiple sclerosis (MS) Sardinian patients and 1,365 healthy ethnically matched controls, analyzing the interactions between HLA-DRB1-DQB1 haplotypes and defining a rank of genotypes conferring a variable degree of risk to the disease. Four haplotypes were found to confer susceptibility (*13:03-*03:01 OR = 3.3, Pc 5.1 × 10(-5), *04:05-*03:01 OR = 2.1, Pc 9.7 × 10(-8),...

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PMID: 23593151
DOI: 10.1371/journal.pone.0059790
PMCID: PMC3620236

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Source receipt: pubmed, retrieved 7 Sept 2026.

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