Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of a single DQ beta chain residue to multiple sclerosis in French Canadians.

Human immunology - 1 Jun 1992

Haegert D G, Francis G S

Abstract excerpt

Putative disease susceptibility and resistance HLA class II alleles were studied in 78 French Canadian multiple sclerosis (MS) patients and 79 controls by using sequence-specific oligonucleotide probes to analyze in vitro amplified DNA (PCR-SSOP) typing). In this relatively homogeneous ethnic gro...

Topics

Alleles
Autoimmune Diseases
Base Sequence
Canada
Disease Susceptibility
Ethnicity
France
Gene Frequency
Genes, MHC Class II
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DQ beta-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Multiple Sclerosis

Polymerase Chain Reaction

Source

Identifiers

PMID: 1429036
DOI: 10.1016/0198-8859(92)90033-j

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1429036-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of a single DQ beta chain residue to multiple sclerosis in French Canadians.PMID 1429036Read ↗

Multiple sclerosis in French Canadians: evidence for HLA class II susceptibility and resistance genes.Semantic proximity Read ↗

HLA-DQ polymorphisms do not explain HLA class II associations with multiple sclerosis in two Canadian patient groups.Semantic proximity Read ↗

No association between susceptibility to multiple sclerosis and HLA-DPB1 alleles in the French Canadian population.Semantic proximity Read ↗

HLA-DQA1 and -DQB1 associations with multiple sclerosis in Sardinia and French Canada: evidence for immunogenetically distinct patient groups.Semantic proximity Read ↗

Susceptibility for multiple sclerosis is determined, in part, by inheritance of a 175-kb region of the TcR V beta chain locus and HLA class II genes.Semantic proximity Read ↗

HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis.Semantic proximity Read ↗

HLA-DR, -DQA1 and -DQB1 associations in Australian multiple sclerosis patients.Semantic proximity Read ↗

HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain).Semantic proximity Read ↗

HLA class II‐associated genetic susceptibility in multiple sclerosis: A critical evaluationSemantic proximity Read ↗

HLA-DQB1 genotype in Sardinian multiple sclerosis: evidence for a key role of DQB1 *0201 and *0302 alleles.Semantic proximity Read ↗

HLA-DP beta and susceptibility to multiple sclerosis: an analysis of caucasoid and Japanese patient populations.Semantic proximity Read ↗

Oligonucleotide dot-blot analysis of HLA-DQ beta alleles associated with multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.