Article
Multiple sclerosis in French Canadians: evidence for HLA class II susceptibility and resistance genes.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 1 Nov 1990
Haegert D G, Michaud M, Francis G S
Abstract excerpt
HLA class II DRB1, DQB1 and DQA1 gene probes were used to study DNA from unrelated French Canadian multiple sclerosis (MS) patients and controls by restriction fragment length polymorphism (RFLP) analysis. An MS-associated and linked series of allele-specific RFLPs or allogenotypes was identified...
Topics
- Adult
- Alleles
- Autoradiography
- Blotting, Southern
- Chromosomes
- DNA Probes
- Ethnicity
- Genes, MHC Class II
- HLA-DQ Antigens
- HLA-DR Antigens
- Humans
- Immunity, Innate
- Multiple Sclerosis
- Nucleic Acid Hybridization
- Quebec
- Restriction Mapping