HLA-DQ polymorphisms are highly selective for peptide binding interactions.

Article

HLA-DQ polymorphisms are highly selective for peptide binding interactions.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1995

Kwok W W, Nepom G T, Raymond F C

Abstract excerpt

The impact of HLA-DQ allelic polymorphism on peptide binding interactions was investigated. MHC class II binding peptides from lambda repressor (lambda R), thyroid peroxidase (TPO), and a modified poly-alanine peptide (AKY) were used in two different binding assays, one with purified DQ molecules...

Topics

Alleles
Amino Acid Sequence
Cells, Cultured
HLA-DQ Antigens
Humans
Molecular Sequence Data
Peptides
Polymorphism, Genetic
Protein Binding

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