Article
Differential expression of insulin-dependent diabetes mellitus-associated HLA-DQA1 alleles in vivo.
European journal of immunology - 1 Jun 1997
Maffei A, Harris P E, Reed E F, Del Pozzo G, Ciullo M, Suciu-Foca N, Guardiola J
Abstract excerpt
The strong association of HLA-DQ genes with insulin-dependent diabetes mellitus (IDDM) susceptibility is persuasive evidence of their central role in the etiology of this autoimmune disease. Among other possibilities, it has been proposed that an unbalanced expression of IDDM-associated DQA, and/or DQB alleles may lead to alterations in the composition of alpha beta heterodimers and preferential expression of a...
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