Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast.

doi:10.1002/j.1460-2075.1991.tb07805.x

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Article

Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast.

The EMBO journal - 1 Sept 1991

Smith V, Barrell B G

Abstract excerpt

We have cloned and sequenced a gene encoding a yeast homologue of the U1 snRNP 70K protein. The gene, SNP1, encodes a protein which has 30% amino acid identity with the human 70K protein and has a predicted molecular weight of 34 kDa. The yeast and human sequences are more closely related to each other than to other (non-U1) RNA-binding proteins, but diverge considerably in their C-terminal portions. In...

Topics

Amino Acid Sequence
Base Sequence
Blotting, Southern
Cloning, Molecular
DNA Probes
DNA, Fungal
Genes, Fungal
Genes, Lethal
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA

RNA, Fungal

Restriction Mapping

Ribonucleoproteins

Ribonucleoproteins, Small Nuclear

Saccharomyces cerevisiae

Source

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Identifiers

PMID: 1714384
DOI: 10.1002/j.1460-2075.1991.tb07805.x
PMCID: PMC452962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1714384-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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