Article
Diversity of immunoglobulin kappa light chain gene rearrangements and evidence for somatic mutation in V kappa IV family gene segments in X-linked agammaglobulinemia.
European journal of immunology - 1 Mar 1993
Timmers E, Hermans M M, Kraakman M E, Hendriks R W, Schuurman R K
Abstract excerpt
X-linked agammaglobulinemia (XLA) is a humoral immunodeficiency disease in man, characterized by an arrest in B lymphocyte differentiation at the precursor B cell stage. The structure of expressed immunoglobulin (Ig) kappa light (L) chain rearrangements of nine B lymphoblastoid cell lines from on...
Topics
- Agammaglobulinemia
- Base Sequence
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Humans
- Immunoglobulin kappa-Chains
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Sequence Alignment
- Sequence Homology, Nucleic Acid
- X Chromosome