Article
Composition of precursor B-cell compartment in bone marrow from patients with X-linked agammaglobulinemia compared with healthy children.
Pediatric research - 1 Feb 2002
Noordzij Jeroen G, de Bruin-Versteeg Sandra, Comans-Bitter W Marieke, Hartwig Nico G, Hendriks Rudolf W, de Groot Ronald, van Dongen Jacques J M
Abstract excerpt
X-linked agammaglobulinemia (XLA) is characterized by a severe B-cell deficiency, resulting from a differentiation arrest in the bone marrow (BM). Because XLA is clinically and immunologically heterogeneous, we investigated whether the B-cell differentiation arrest in BM of XLA patients is heterogeneous as well. First, we analyzed BM samples from 19 healthy children by flow cytometry. This resulted in a normal...
Topics
- Adolescent
- Agammaglobulinaemia Tyrosine Kinase
- Agammaglobulinemia
- Amino Acid Substitution
- Antigens, CD20
- Antigens, CD34
- B-Lymphocytes
- Biomarkers
- Bone Marrow Cells
- Cell Differentiation
- Child
- Child, Preschool
- Female