A mutated promoter of a human Ig V lambda gene segment is associated with reduced germ-line transcription and a low frequency of rearrangement.

Abstract excerpt

Several explanations for skewed variable (V) gene usage in the expressed Ig repertoire have been put forth, ranging from cellular selection to differences in the actual rearrangement frequencies of individual V gene segments. In this report we study V gene usage in human Ig lambda rearrangements in an in vitro system, thus largely avoiding selective forces. We find a significant bias in V lambda gene usage in...

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