Article
A mutated promoter of a human Ig V lambda gene segment is associated with reduced germ-line transcription and a low frequency of rearrangement.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1995
Stiernholm N B, Berinstein N L
Abstract excerpt
Several explanations for skewed variable (V) gene usage in the expressed Ig repertoire have been put forth, ranging from cellular selection to differences in the actual rearrangement frequencies of individual V gene segments. In this report we study V gene usage in human Ig lambda rearrangements...
Topics
- Amino Acid Sequence
- Antibody Diversity
- Base Sequence
- DNA Mutational Analysis
- Gene Expression Regulation
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Lymphoma, B-Cell
- Methylation
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Sequence Homology, Nucleic Acid
- Transcription, Genetic
- Tumor Cells, Cultured