Aberrant rearrangements within the immunoglobulin heavy chain locus in hairy cell leukemia.

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Article

Aberrant rearrangements within the immunoglobulin heavy chain locus in hairy cell leukemia.

Leukemia & lymphoma - 1 Jan 1994

Kayano H, Dyer M J, Zani V J, Laffan M A, Matutes E, Asou N, Katayama I, Catovsky D

Abstract excerpt

The cell surface expression of multiple immunoglobulin heavy chain (IGH) isotypes, preferentially observed in hairy cell leukemia (HCL), is incompatible with the deletion model of IGH class switching, and alternative models involving RNA-splicing have been proposed. To help discriminate between t...

Topics

Alleles
DNA, Neoplasm
Gene Deletion
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Humans
Immunoblotting
Immunoglobulin A
Immunoglobulin Constant Regions
Immunoglobulin Fragments
Immunoglobulin G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Heavy Chains

Immunoglobulin Isotypes

Immunoglobulin Switch Region

Immunophenotyping

Introns

Leukemia, Hairy Cell

RNA Splicing

Source

Open in PubMed

Identifiers

PMID: 7820052

Genes

IGH
BCL2
BCL3
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7820052-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Aberrant rearrangements within the immunoglobulin heavy chain locus in hairy cell leukemia.PMID 7820052Read ↗

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