Somatic mutations in the Ig variable region genes and expression of novel Cmu-germline transcripts in a B-lymphoma cell line ("Farage") not producing Ig polypeptide chains.

Abstract excerpt

Non-Hodgkin's B-lymphomas (B-NHL) are a very heterogeneous group of B-cell neoplasias originating from the germinal centers of lymphatic follicles. Thus, they represent a suitable experimental model to study the molecular basis of certain key events which take place in the lymphatic follicles, in...

Topics

• Amino Acid Sequence
• B-Lymphocytes
• Base Sequence
• Cloning, Molecular
• DNA, Neoplasm
• Gene Rearrangement, B-Lymphocyte, Heavy Chain
• Gene Rearrangement, B-Lymphocyte, Light Chain
• Humans
• Immunoglobulin Variable Region
• Immunoglobulin kappa-Chains
• Immunoglobulin mu-Chains
• Leukopoiesis
• Lymphoma, B-Cell
• Molecular Sequence Data
• Mutation
• Peptides
• Phenotype
• RNA, Messenger