Article
Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study.
BMJ (Clinical research ed.) - 10 Sept 1994
Kuusisto J, Koivisto K, Kervinen K, Mykkänen L, Helkala E L, Vanhanen M, Hänninen T, Pyörälä K, Kesäniemi Y A, Riekkinen P
Abstract excerpt
OBJECTIVE: To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample. DESIGN: Cross sectional population based study. SUBJECTS: 980 people aged 69 to 78 (349 men, 631 women). SETTING: Population of Kuopio, eastern Finland. MAIN OUTCOME MEASURES: Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and...
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