Diverse point mutations in the human gene for polymorphic N-acetyltransferase.

doi:10.1073/pnas.88.14.6333

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Article

Diverse point mutations in the human gene for polymorphic N-acetyltransferase.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1991

Vatsis K P, Martell K J, Weber W W

Abstract excerpt

Classification of humans as rapid or slow acetylators is based on hereditary differences in rates of N-acetylation of therapeutic and carcinogenic agents, but N-acetylation of certain arylamine drugs displays no genetic variations. Two highly homologous human genes for N-acetyltransferase (NAT; a...

Topics

Acetylation
Arylamine N-Acetyltransferase
Base Sequence
DNA
Ethnicity
Humans
Leukocytes
Liver
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Polymerase Chain Reaction
Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2068113
DOI: 10.1073/pnas.88.14.6333
PMCID: PMC52077

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2068113-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

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Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.