Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diverse point mutations in the human gene for polymorphic N-acetyltransferase.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1991

Vatsis K P, Martell K J, Weber W W

Abstract excerpt

Classification of humans as rapid or slow acetylators is based on hereditary differences in rates of N-acetylation of therapeutic and carcinogenic agents, but N-acetylation of certain arylamine drugs displays no genetic variations. Two highly homologous human genes for N-acetyltransferase (NAT; arylamine acetyltransferase, acetyl CoA:arylamine N-acetyltransferase, EC 2.3.1.5), NAT1 and NAT2, presumably code for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA
Share to Liver

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Oligonucleotide Probes

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2068113
DOI: 10.1073/pnas.88.14.6333
PMCID: PMC52077

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diverse point mutations in the human gene for polymorphic N-acetyltransferase.PMID 2068113Read ↗

Polymorphism of human acetyltransferases.Semantic proximity Read ↗

Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus.Semantic proximity Read ↗

Polymorphisms of N-acetyltransferase genes.Semantic proximity Read ↗

Molecular mechanism of slow acetylation of drugs and carcinogens in humans.Semantic proximity Read ↗

Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.Semantic proximity Read ↗

Determination of human NAT2 acetylator genotype by restriction fragment-length polymorphism and allele-specific amplification.Semantic proximity Read ↗

Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes.Semantic proximity Read ↗

Sequences and expression of alleles of polymorphic arylamine N-acetyltransferase of human liver.Semantic proximity Read ↗

Homozygous rapid arylamine N-acetyltransferase (NAT2) genotype as a susceptibility factor for lung cancer.Semantic proximity Read ↗

Human acetyltransferase polymorphisms.Semantic proximity Read ↗

Arylamine N-acetyltransferase 2 slow acetylator polymorphisms in unrelated Iranian individuals.Semantic proximity Read ↗

Genotyping of the polymorphic N-acetyltransferase (NAT2*) gene locus in two native African populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.