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Article

Telomere directed fragmentation of mammalian chromosomes

1 Jan 1993

Abstract excerpt

Cloned human telomeric DNA can integrate into mammalian chromosomes and seed the formation of new telomeres. This process occurs efficiently in three established human cell lines and in a mouse embryonic stem cell line. The newly seeded telomeres appear to be healed by telomerase. The seeding of new telomeres by cloned telomeric DNA is either undetectable or very inefficient in non-tumourigenic mouse or human...

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Identifiers

PMID: 8441617
DOI: 10.1093/nar/21.1.27

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