Article

Neotelomere formation by human telomerase

2022-11-01

Abstract excerpt

<h4>Summary</h4> The maintenance of genome integrity requires that telomerase action be limited to telomeres and not convert DSBs into neotelomeres. Using the breakpoint sequence from an apparent germline neotelomere formation event, we developed an assay to detect and quantify telomeric repeat addition at Cas9-programmed DSBs in human cells. The data show that telomerase can add telomeric repeats to DSBs and tha...

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Literature Corpus work: c962ecad-d72a-589d-afac-e2df567628c0
DOI: 10.1101/2022.10.31.514589

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