Stringent sequence requirements for the formation of human telomeres.

doi:10.1073/pnas.91.19.8861

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Article

Stringent sequence requirements for the formation of human telomeres.

13 Sept 1994

Abstract excerpt

In human cells, transfection of telomeric T2AG3 repeats induces the formation of functional telomeres at previously interstitial sites. We report that telomere formation has stringent sequence requirements. While (T2AG3)n telomere seeds formed telomeres in approximately 70% of the transfected cells, five T2AG3-related heterologous telomeric DNAs seeded new telomeres in < 5% of the transfectants. Telomere...

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Share to Advanced biosensing and bioanalysis techniques
Share to Chromosomal and Genetic Variations
Share to Telomeres, Telomerase, and Senescence

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PMID: 8090736
DOI: 10.1073/pnas.91.19.8861

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