Article
Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements.
Nucleic acids research - 1 Apr 2010
Letsolo Boitelo T, Rowson Jan, Baird Duncan M
Abstract excerpt
Telomere fusion is an important mutational event that has the potential to lead to large-scale genomic rearrangements of the types frequently observed in cancer. We have developed single-molecule approaches to detect, isolate and characterize the DNA sequence of telomere fusion events in human cells. Using these assays, we have detected complex fusion events that include fusion with interstitial loci adjacent to...
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