Article
The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line.
Molecular cancer research : MCR - 1 Mar 2005
Sabatier Laure, Ricoul Michelle, Pottier Géraldine, Murnane John P
Abstract excerpt
Spontaneous telomere loss has been proposed as an important mechanism for initiating the chromosome instability commonly found in cancer cells. We have previously shown that spontaneous telomere loss in a human cancer cell line initiates breakage/fusion/bridge (B/F/B) cycles that continue for many cell generations, resulting in DNA amplification and translocations on the chromosome that lost its telomere. We have...
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