Article
Biogenesis of von Willebrand factor-containing organelles in heterologous transfected CV-1 cells.
The EMBO journal - 1 Feb 1993
Voorberg J, Fontijn R, Calafat J, Janssen H, van Mourik J A, Pannekoek H
Abstract excerpt
Von Willebrand factor (vWF) is a multimeric protein involved in the adhesion of platelets to an injured vessel wall. vWF is synthesized by the endothelial cell and the megakaryocyte as a precursor protein (pro-vWF) that consists of four repeated domains, denoted D1-D2-D'-D3-A1-A2-A3-D4-B1-B2-B3-C1-C2. Previously, we have defined the domains on the pro-vWF molecule involved in dimerization as well as the domains...
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