Article
Caveolin-1 is an aggresome-inducing protein.
Scientific reports - 8 Dec 2016
Tiwari Ajit, Copeland Courtney A, Han Bing, Hanson Caroline A, Raghunathan Krishnan, Kenworthy Anne K
Abstract excerpt
Caveolin-1 (Cav1) drives the formation of flask-shaped membrane invaginations known as caveolae that participate in signaling, clathrin-independent endocytosis and mechanotransduction. Overexpression or mutations of Cav1 can lead to its mistrafficking, including its accumulation in a perinuclear compartment previously identified as the Golgi complex. Here, we show that in the case of overexpressed Cav1-GFP, this...
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